I have been working as a rheumatologist for over 10 years in Japan, and then joining Dr. Andrew D. Luster’s laboratory at Massachusetts General Hospital/Harvard Medical School between 2013 and 2018 to investigate the pathogenesis of inflammatory arthritis. After that, I started working as an Associate Professor in Division of Cell Biology, Nippon Medical School between 2018 and 2022 to study leukocytes migratory behaviour in Central Nervous System (CNS) in vivo. Recently, I am appointed to a Professor and Chair of Immunology and Medicine at the St. Marianna University School of Medicine. My recent major concern is targeting chemoattractant (CA) system on several diseases with CNS involvement such as CNS lupus, multiple sclerosis (MS), Alzheimer diseases (AD) and viral encephalitis. I discovered that the lipid mediator lysophosphatidic acid (LPA) and its G protein-coupled receptor LPA₁ are essential for development of arthritis (Arthritis and Rheumatology 2013), and described the role of LPA₁ on RA fibroblast like synoviocytes (Arthritis Research and Therapy 2014). In addition, my other works demonstrated that the role of CXCR7 (Arthritis and Rheumatology 2010), ChemR23 (Arthritis Research and Therapy 2011), cannabinoid (BMC Musculoskeletal Disorders 2014) and CCR9 (Arthritis Research and Therapy 2014) on inflammatory arthritis. I am interested in continuing my studies and deepening my understanding of the role of CAs in the pathogenesis of RA. Recently, we have developed a new in vivo imaging the joint to study the leukocytes migratory behaviour in the inflamed joint of mice with immune-complex (IC) induced arthritis (Methods in Enzymology 2016). We have clarified the new paradigm of type III hypersensitivity that complement C5a “directly” initiates neutrophil adhesion in the IC-induced arthritis (Science Immunology 2017). More recently, we have discovered the new function for C5aR2 transports C5a to vessel lumen to initiate first neutrophil adhesion igniting inflammation (Science Immunology 2019) In addition to inflammatory arthritis, I have defined the pathogenic role of chemokines on cerebral Malaria (JCI Insight 2018) and viral encephalitis (Cell Reports 2020). Now, we are studying the leukocytes migration cascade on animal models of CNS lupus, MS and AD using in vivo brain imaging.